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Augmentation of olanzapine in treatment-resistant schizophrenia

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  • Review Paper
  • Chemistry
  • Medicine


Antipsychotics summarized – Consumer Reports Health What are antipsychotic drugs? Antipsychotics are prescription drugs used to treat schizophrenia. They can also be used—along with other drugs—to help treat bipolar disorder. The exact causes of schizophrenia and bipolar disorder are not fully known. However, they are linked to changes in chemicals in the brain that influence behavior, mood, and thinking. Antipsychotics work by affecting these chemicals. Antipsychotic drugs do not help everyone. Schizophrenia is a brain disorder that makes it hard to pay attention, interact with other people, and tell the difference between what is real and what is not real. Unfortunately, antipsychotic drugs won’t help about one out of every five people with schizophrenia who take them. Another one in three to four people only get a limited benefit. And for those who respond best, their symptoms are usually only reduced by about half. Bipolar disorder is marked by sharp swings between feeling very good (manic) and feeling very low (de- pressed). When used for a short time, antipsychotics help 50 to 75 percent of people with bipolar disorder have fewer symptoms of mania. Antipsychotic drugs can have serious side effects. Most people who take antipsychotic drugs have one or more side effects. These can include blurred vision, dizziness, drowsiness, dry mouth, muscle stiffness or weakness, restlessness, sexual problems, spasms and tremors, and weight gain. More serious side effects can include diabetes, a higher risk for heart disease and stroke, seizures, and a drop in the number of white blood cells that fight infection. Side effects can ease or go away with time, but many people stop taking the drugs because of side effects. Antipsychotic drugs are expensive. There are two generations of antipsychotic drugs: the first-generation, or older antipsychotics, and the second-generation, or “atypical” antipsychotics. Many of the older drugs are available as generics,

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