Summary 1. Gangrene of an extremity is described in two newborn infants, increasing to fifty-two the number of reported cases. The reported instances are reviewed in respect to age of onset, location of gangrene, probable causes, and outcome. 2. Birth trauma, emboli from thrombotic closure of the ductus arteriosus, and thrombosis of the umbilical arteries are discussed as likely causes of this condition. 3. Emphasis is placed on early recognition and vigorous treatment with anticoagulants and vasodilating measures. 4. Conservatism is recommended in the consideration of amputation.