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A remote substituent as a control element in indium-mediated allylation reactions in aqueous media: highly diastereoselective synthesis of 1,3-amino alcohols

Authors
Journal
Tetrahedron Letters
0040-4039
Publisher
Elsevier
Publication Date
Volume
41
Issue
33
Identifiers
DOI: 10.1016/s0040-4039(00)01040-6
Keywords
  • Allylation
  • 1
  • 3-Amino Alcohols
  • High Diastereoselectivity
  • Indium
  • Remote Substituent

Abstract

Abstract A new method for the stereoselective synthesis of 1,3-amino alcohols based on the indium-mediated allylation of keto ester ( R,S)- 2 in aqueous media, resulting from shielding of one face by a remote substituent, was developed to be a useful method for acyclic stereocontrol in the absence of any obvious steric interaction.

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