Objective:Dyslipidaemia in patientswith diabetesmellitus leads to atherosclerosis and this contributes to erectile dysfunction (ED). This study set out to characterize the lipid profile pattern in diabetic patients with erectile dysfunction.Subject andMethods:Aprospective, cross sectional study carried out at the diabetes clinic of the University of Benin Teaching Hospital. Forty diabetic subjects with erectile dysfunction and thirty-two diabetic subjects without erectile dysfunction who served as controls were recruited for the study. Data obtained include anthropometric indices and fasting serum lipids.Data was analyzed with SPSS version 10.Results: The prevalence of dyslipidaemia was 82.5%in the ED subjects and 68.7%in the control group and this difference was not statistically significant. The ED subjects had greater means of age, body mass index and waist hip ratio than the control group but this was not statistically significant. The mean values of the lipid profile was higher in the EDpatients except for the HDL cholesterol level. Elevated total cholesterolwas themost common abnormal lipid parameter,while elevated triglyceridewas the least common abnormal parameter seen in both groups.Conclusion: The prevalence of dyslipidaemia in diabetic subjects with erectile dysfunction is high. Efforts must be put in place to treat dyslipidaemia and other cardiovascular risk factors aggressively to prevent or ameliorate this complication.Niger Med J, Vol. 49, No. 4, Oct– Dec 2008, 81–83Keywords:Lipid profile, erectiledysfunction, diabetesmellitus, BeninCity.