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The Anaphase-Promoting Complex:Proteolysis in Mitosis and Beyond

Authors
Journal
Molecular Cell
1097-2765
Publisher
Elsevier
Publication Date
Volume
9
Issue
5
Identifiers
DOI: 10.1016/s1097-2765(02)00540-3
Disciplines
  • Biology

Abstract

Abstract Key events in mitosis such as sister chromatid separation and subsequent inactivation of cyclin-dependent kinase 1 are regulated by ubiquitin-dependent proteolysis. These events are mediated by the anaphase-promoting complex (APC), a cell cycle-regulated ubiquitin ligase that assembles multiubiquitin chains on regulatory proteins such as securin and cyclins and thereby targets them for destruction by the 26S proteasome.

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