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Is 3 Weeks of Exercise Enough to Change Blood Pressure and Cardiac Redox State in Hypertensive Rats?

Authors
  • Jakovljevic, Biljana
  • Plecevic, Sasa
  • Petkovic, Anica1
  • Turnic, Tamara Nikolic1
  • Milosavljevic, Isidora1
  • Radoman, Kristina
  • Srejovic, Ivan2
  • 1 Faculty of Medical Sciences, Department of Pharmacy, Serbia , (Serbia)
  • 2 Faculty of Medical Sciences, Department of Physiology, Serbia , (Serbia)
Type
Published Article
Journal
Serbian Journal of Experimental and Clinical Research
Publisher
Sciendo
Publication Date
Dec 31, 2019
Volume
20
Issue
4
Pages
319–326
Identifiers
DOI: 10.1515/sjecr-2017-0049
Source
De Gruyter
Keywords
License
Green

Abstract

The investigation was aimed to evaluate the effects of 3-weeks swimming exercise on blood pressure and redox status in high-salt-induced hypertensive rats. Male Wistar albino rats (n=40, 6 weeks old) were divided into 4 groups: 1. hypertensive rats that swam for 3 weeks; 2. sedentary hypertensive control rats; 3. normotensive rats that swam for 3 weeks; 4. sedentary normotensive control rats. Hypertensive animals were on high concentrated sodium (8% NaCl) solution for 4 weeks (period of induction of hypertension). After sacrificing, hearts were isolated and perfused according to Langendorff technique at gradually increased coronary per-fusion pressure from 40–120 cmH2O. The oxidative stress markers were determined in coronary venous effluent: the index of lipid peroxidation (measured as TBARS), nitrites (NO2−), superoxide anion radical (O2−) and hydrogen peroxide (H2O2). Swimming did not lead to significant changes in levels of TBARS, NO2−, O2− in any of compared groups while levels of H2O2 were significantly higher in swimming hyper-tensive group comparing to swimming normotensive group at coronary perfusion pressure of 80–120 cmH2O. Our results indicate that the short-term swimming start to reduce blood pressure. In addition it seems that this type of swimming duration does not promote cardiac oxidative stress damages.

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