The 3-O-(3',3'-dimethylsuccinyl) derivative of betulinic acid (DSB) inhibits the assembly of virus-like particles in HIV-1 Gag precursor-expressing cells.

Pierre Boulanger; Sandrina DaFonseca; Armand Blommaert; Pascale Coric; Saw See Hong; Serge Bouaziz

The 3-O-(3',3'-dimethylsuccinyl) derivative of betulinic acid (DSB) inhibits the assembly of virus-like particles in HIV-1 Gag precursor-expressing cells.

Authors

Boulanger, Pierre
DaFonseca, Sandrina
Blommaert, Armand
Coric, Pascale
Hong, Saw See
Bouaziz, Serge

Type

Published Article

Journal

Diabetes care

Publication Date

Jan 01, 2007

Volume

12

Issue

8

Pages

1185–1203

Identifiers

PMID: 18240859

Source

USPC - SET - SVS

License

Unknown

Abstract

Sequence alignment and three-dimensional modelling by homology of the CA-SP1-NC junction in HIV-1, SLVmac251 and Pr72Gag(MLV-HIV) suggested that a higher hydrophilic character of the CA region immediately upstream to the HIV-1 CA-SP1 junction, as occurred in Pr72Gag(MLV-HIV), correlated with a lower DSB sensitivity.

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. This record was last updated on 10/03/2017 and may not reflect the most current and accurate biomedical/scientific data available from NLM. The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/18240859

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