Abstract This paper updates and expands upon a previous study [Remer, D.S., Mattos, F.B., 2003. Cost and scale-up factors, international inflation indexes and location factors. International Journal of Production Economics 84, 16] on cost and location factors used in the US and internationally. The current study includes 47 US cost and location factors and 30 international cost and location factors for 12 countries. In addition, cost scale-up factors for a wide variety of equipment, plants, and processes from air pollution abatement to waste-to-energy facilities to commercial airplanes are presented. This study reviews the use of these indexes and scale-up factors, and presents caveats for their use.