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Spectroscopic studies on the interaction of hypocrellin A and hemoglobin

Authors
Journal
Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy
1386-1425
Publisher
Elsevier
Publication Date
Volume
72
Issue
1
Identifiers
DOI: 10.1016/j.saa.2008.09.009
Keywords
  • Hypocrellin A
  • Hemoglobin
  • Uv–Vis Absorption Spectroscopy
  • Fluorescence Spectroscopy
  • Electron Paramagnetic Resonance Spectroscopy
Disciplines
  • Medicine
  • Physics

Abstract

Abstract The spectrophotometric and spectrofluorimetric studies revealed that hemoglobin (Hb) could interact with hypocrellin A, a photosensitizing drug used in photodynamic therapy. It was found that this kind of interaction can induce the conformational changes in Hb. In addition, based on fluorescence quenching titration and electron paramagnetic resonance spectroscopy results, the binding parameters, thermodynamic parameters are obtained. The quenching mechanism is also proposed.

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