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In vitroand computational studies of transdermal perfusion of nanoformulations containing a large molecular weight protein

Authors
Journal
Colloids and Surfaces B Biointerfaces
0927-7765
Publisher
Elsevier
Publication Date
Volume
108
Identifiers
DOI: 10.1016/j.colsurfb.2013.02.032
Keywords
  • Protein
  • Surfactant
  • Nanodispersion
  • Transdermal Perfusion
  • Hydrophilic Macromolecules
Disciplines
  • Biology
  • Medicine

Abstract

Abstract Transdermal perfusion of a large protein is reported for the first time, using a nanoemulsion of bovine serum albumin (66kDa) of 160nm prepared by a solid-in-oil (S/O) process. Molecular dynamics simulations confirmed skin permeation by these formulations, with integration of the protein into the lipid bilayers. These results demonstrate the real possibility of delivering large proteins transdermally for a range of medical and cosmetic applications.

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