Publisher Summary This chapter evaluates the performance characteristics of borate-modified oriented strandboard (OSB) manufactured using southern wood species, according to the industry test standards. The static bending properties of the OSB are affected little at the room condition by the added borate. The internal bond strength is, however, generally smaller at the higher borate loading levels. Thickness swelling (TS) under the 24-hour water soaking increases with the increase in borate content, especially for calcium borate. Part of the borate leaches out under the water soaking condition due to the glueline washing and decomposition of the borate to form less water-soluble boric acid. The use of borate with a smaller particle size helps reducing TS and leaching rate significantly. Laboratory no-choice termite tests indicate that both zinc and calcium borate modified OSB resist Formosan Subterranean Termites (FSTs) well. Thus, termite resistant OSB with required mechanical and physical performance could be successfully developed using southern wood species. This technology will allow more OSB producers to manufacture chemically modified OSB to meet increasing market demands.