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Metabolism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) by bovine brain microvessel endothelial cells

Authors
Journal
Brain Research
0006-8993
Publisher
Elsevier
Publication Date
Volume
501
Issue
1
Identifiers
DOI: 10.1016/0006-8993(89)91039-1
Keywords
  • 1-Methyl-4-Phenyl-1
  • 2
  • 3
  • 6-Tetrahydropyridine
  • 1-Methyl-4-Phenyl-2
  • 3-Dihydropyridine
  • 1-Methyl-4-Phenylpyridine
  • Brain Endothelium
  • Blood-Brain Barrier
  • Monoamine Oxidase

Abstract

Abstract Incubation of bovine brain microvessel endothelial cell monolayers with the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine led to the monoamine oxidase (MAO)-mediated formation of the oxidative metabolites 1-methyl-4-phenyl-2,3-dihydropyridine and 1-methyl-4-phenylpyridine (MPP +). The flux of the low nanomolar concentrations of [ 3H]MPP + across endothelial cell monolayers appeared to be restricted, probably due to the oxidation by MAO. [ 3H]MPP + did not significantly cross endothelial cell monolayers.

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