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Low-grade adenosquamous carcinoma of the breast—A case report with aBRCA1germline mutation

Authors
Journal
Pathology - Research and Practice
0344-0338
Publisher
Elsevier
Publication Date
Volume
206
Issue
7
Identifiers
DOI: 10.1016/j.prp.2010.01.008
Keywords
  • Low-Grade Adenosquamous Carcinoma
  • Pathology
  • Immunohistochemistry
  • Breast
  • Brca1
Disciplines
  • History
  • Medicine

Abstract

Abstract Breast cancers occurring in women with germline BRCA1 mutations tend to fall into the category of triple-negative or basal-like phenotypes, such as metaplastic carcinoma. Low-grade adenosquamous carcinoma of the breast is a rare variant of metaplastic carcinoma. We present the case of a 49-year-old woman with a past medical history of invasive ductal breast carcinoma 13 years ago, and who was recently diagnosed as having a low-grade adenosquamous carcinoma in the same breast. Genetic analysis of blood DNA revealed a BRCA1 mutation. To our knowledge, BRCA1 mutation in association with a low-grade adenosquamous carcinoma of the breast has not yet been reported. Thus, it may be important to consider the possibility of an association, but supplemental studies are needed.

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