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Mechanisms of oxidant-induced changes in erythrocytes

Authors
Journal
Agents and Actions
0065-4299
Publisher
Springer-Verlag
Publication Date
Source
Legacy
Disciplines
  • Chemistry
  • Medicine

Abstract

There is an increasing body of experimental studies demonstrating the toxic effects of oxygen-derived free radicals. Evidence supports an important role for free radicals in ischemic injuries, inflammation, and chemical-induced tissue injury. Free radicals are involved in normal biochemical processes like oxidative reduction and cellular metabolism; however, they also mediate disease processes. The participation of oxygen free radicals in lysis of red cells is important in some situations of intravascular hemolysis. This article will review neutrophil-derived oxygen free radicals, emphasizing: (1) their effects on the erythrocyte and (2) how these effects may be attenuated.

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