Affordable Access

Publisher Website

Cysteinyldopamine is not incorporated into neuromelanin

Authors
Journal
Neuroscience Letters
0304-3940
Publisher
Elsevier
Publication Date
Volume
131
Issue
1
Identifiers
DOI: 10.1016/0304-3940(91)90336-r
Keywords
  • Neuromelanin
  • Cysteinyldopamine
  • Cysteinylnorepinephrine
  • Cysteinyldopa
  • Substantia Nigra
  • Dopamine
  • Norepinephrine
  • Parkinson'S Disease

Abstract

Abstract The pigment of human substantia nigra, neuromelanin, has been thought to be derived from dopamine. To examine the genesis of neuromelanin, we advanced a new hypothesis that neuromelanin is formed by oxidation of dopamine and cysteinyldopamine. On the basis of this hypothesis, synthetic neuromelanins were obtained by tyrosinase oxidation of dopamine in the presence of various ratios of cysteine and were hydrolyzed with hydriodic acid to obtain 4-amino-3-hydroxyphenylethylamine (AHPEA). The AHPEA content in these synthetic melanins was shown to be proportional to the sulfur content. Eleven samples of human substantia nigra were treated as well and contents of AHPEA were found to be only trace amounts. These results suggest that cysteinyldopamine may not be incorporated into neuromelanin.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

Cysteinyldopamine is not incorporated into neurome...

on Neuroscience Letters Sep 30, 1991

Evolutionary role of neuromelanin.

on Proceedings of the Western Pha... 1975

Isolation of neuromelanin granules.

on Current protocols in cell biol... December 2008
More articles like this..