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Synthesis of di- and triphosphate ester analogsviaa modified Michaelis-Arbuzov reaction

Authors
Journal
Tetrahedron Letters
0040-4039
Publisher
Elsevier
Publication Date
Volume
36
Issue
29
Identifiers
DOI: 10.1016/0040-4039(95)01009-7
Disciplines
  • Biology

Abstract

Abstract For the first time, benzyl phosphites allowed the preparation of a set of polyphosphonates from chloromethyl halides via the Michaelis-Arbuzov reaction performed under vacuum. Regioselective mono-deprotection or complete deprotection of these phosphonates provide useful building blocks for the synthesis of biological phosphate analogs.

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