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Dehydroepiandrosterone attenuates the spontaneous elevation of serum IgE level in NC/Nga mice

Authors
Journal
Immunology Letters
0165-2478
Publisher
Elsevier
Publication Date
Volume
79
Issue
3
Identifiers
DOI: 10.1016/s0165-2478(01)00285-1
Keywords
  • Atopic Dermatitis
  • Dehydroepiandrosterone
  • Ige
  • Interleukin-6
  • Nc/Nga Mouse
  • Th1/Th2 Balance

Abstract

Abstract Dehydroepiandrosterone (DHEA) and its sulfate derivatives are known to affect host immune function; however if such hormones influence the development of atopic dermatitis has not yet been clarified. In this study, we examined the effects of DHEA on the allergic process using NC/Nga mouse, a model animal of human atopic dermatitis. The administration of DHEA profoundly suppressed the spontaneous elevation of both serum IgE and interleukin-6 levels in NC/Nga mice during the observation period. These results indicate that DHEA promotes a shift in Thl/Th2 balance toward Th1-dominant immunity, and thus may be one of the effective alternatives in treating atopic dermatitis.

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