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A Short Textbook of Radiotherapy. 4th Edition

British Journal of Cancer
Nature Publishing Group
Publication Date
  • Book Review
  • Biology
  • Chemistry
  • Ecology
  • Geography
  • Medicine


768 BOOK REVIEWS presence of nitroso-compounds is given for human and animal foodstuffs, in tobacco smoke, in the laboratory and factory environ- ments and in confined spaces (such as inside new cars). An examination of the fate of ingested nitrate and nitrite in man and a variety of other organisms suggests that the ratio of nitrate excreted in urine to the total amount ingested is influenced by the degree of reduction to nitrite within the organism, thus indicating the possible in vivo formation of nitroso compounds. The section Experimental Pathology includes a comparison of the degree of skin penetration by nitrosamines of environmental importance, and an interesting series of experiments suggesting that very low levels of other chemical carcinogens can contribute to the carcingoenic action of a nitrosamine. The volume ends with a very short, but usefuil, set of suggestions indicating priorities for future work under the 4 main topics considered. P. J. O'CONNOR Cloning of Human Tumour Stem Cells. Ed. S. E. SALMON (1981). New York: Alan R. Liss Inc. 367 pp. This volume deals in depth with a topic which is of considerable interest both to basic scientists and clinicians working in the field of cancer chemotherapy. It contains 23 chapters dealing with all aspects of cloning and drug-sensitivity testing of human tum- ours in vitro. However one cannot avoid the feeling that a somewhat biased view is presented since 13 of the 23 chapters are co-authored by the editor S. E. Salmon, and most of the other 10 chapters are written by members of the same group. From the data presented in the various chapters it is obvious that the Arizona group has had considerable success in cloning human tumours of a variety of histological types, and in using measurements of their drug sensitivity in vitro for both retrospective and predictive studies of the sensitivity of individual tumours to therapy. However there is little indication in this volume that the methods and results are reproducible in other labo

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