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Modifications of the isonipecotic acid fragment of SNS-032: Analogs with improved permeability and lower efflux ratio

Authors
Journal
Bioorganic & Medicinal Chemistry Letters
0960-894X
Publisher
Elsevier
Publication Date
Volume
18
Issue
23
Identifiers
DOI: 10.1016/j.bmcl.2008.09.099
Keywords
  • Cdk
  • Cyclin
  • Sns-032
  • Kinase

Abstract

Abstract Modifications of the isonipecotic acid fragment of SNS-032 results in analogs which are more permeable and lower effluxed than SNS-032. The enantiomerically pure synthesis and the in vivo profile of analog 20 is described.

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