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약용식물 오수유로부터 다제약제 내성 조절물질의 분리

Authors
  • Sung Woo Lee
  • Bang Yeon Hwang
  • Se Eun Kim
  • Hwan Mook Kim
  • Young Ho Kim
  • Kyong Soon Lee
  • Jung Joon Lee
  • Jai-Seup Ro
Publication Date
Jan 01, 1995
Source
KRIBB Repository
Keywords
License
Unknown
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Abstract

Preliminary screening test of modulators for multidrug resistance with 400 medicinal plants was carried out by using human multidrug resistance cell line, KB-V1. Among active medicinal plants, the unripe fruits of Evodia officinalis showed a potent modulating activity of MDR. From MeOH extract of this plant, we isolated two indole alkaloids, rutaecarpine (1) and evodiamine (2), by repeated silicagel column chromatography. Rutaecarpine increased the cytotoxicities of vinblastine and taxol against multidrug resistance cells, but evodiamine showed no modulating activity in spite of its potent cytotoxic activities.

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