Affordable Access

Publisher Website

Dissolution enhancement of efavirenz by solid dispersion and PEGylation techniques

International Journal of Pharmaceutical Investigation
Medknow Publications
Publication Date
DOI: 10.4103/2230-973x.76726
  • Original Research Article
  • Economics


Background: Efavirenz is the preferred nonnucleotide reverse transcriptase inhibitor for first-line antiretroviral treatment in many countries. It is orally active and is specific for human immunodeficiency virus type 1. Its effectiveness can be attributed to its long half-life, which is 52–76 h after multiple doses. The drug is having poor water solubility. The formulation of poorly soluble drug for oral delivery will be one of the biggest challenges for formulation scientists in the research field. Among the available approaches, the solid dispersion technique has often proved to be the most commonly used method in improving dissolution and bioavailability of the drugs because of its simplicity and economy in preparation and evaluation. Materials and Methods: Solid dispersions were prepared by solvent evaporation and physical mixture methods by using polyethylene glycol as the hydrophilic carrier and PEGylated product was also prepared. The prepared products were evaluated for various parameters, such as polymer interaction, saturation solubility study, and drug release studies. The drug release data were analyzed by fitting it into various kinetic models. Results: There is an improvement in the dissolution from 16% to 70% with solid dispersion technology. Higuchi model was found to be the best fit model. Conclusion: Solid dispersion is the simple, efficient, and economic method to improve the dissolution of the poorly water-soluble drugs.

There are no comments yet on this publication. Be the first to share your thoughts.


Seen <100 times

More articles like this

Dissolution enhancement of efavirenz by solid disp...

on International journal of pharm... January 2011

Formulation development and dissolution rate enhan...

on Indian Journal of Pharmaceutic... May 2013

Formulation Development and Dissolution Rate Enhan...

on Indian Journal of Pharmaceutic... Jan 01, 2013

Enhancement of dissolution of glyburide by solid d...

on International Journal of Pharm... Jan 01, 1995
More articles like this..