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Predictive factors with reference to low-risk of metastases in squamous cell carcinoma in the vulvar region

Authors
Journal
Gynecologic Oncology
0090-8258
Publisher
Elsevier
Publication Date
Volume
21
Issue
2
Identifiers
DOI: 10.1016/0090-8258(85)90252-5

Abstract

Abstract Among 122 patients operated upon for squamous cell carcinoma in the vulvar region 14 variables were investigated by a logistic regression analysis to determine their predictive value as to the presence/absence of metastases to the inguinal nodes. Factors of predictive value proved to be hyperchromasia, polymorphism, involvement of the clitoris, depth of invasion, and tumor size. On the basis of these variables, three different models of lowrisk groups were set up. Model I comprised patients whose tumors showed slight hyperchromasia and did not involve the clitoris [metastatic rate: observed 0, estimated 2.1% (0.4–9.8%)]. Model II comprised patients whose tumors showed slight hyperchromasia, did not involve the clitoris, and measured <4 cm [metastatic rate: observed 0, estimated 1.6% (0.3–7.8%)]. Model III comprised patients whose tumors showed slight hyperchromasia, did not involve the clitoris, and had an invasion depth of ⩽5 mm [metastatic rate: observed 0, estimated 1.3% (0.2–7.1%)].

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