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A polymorphism in the tau gene associated with risk for Alzheimer's disease

Authors
Journal
Neuroscience Letters
0304-3940
Publisher
Elsevier
Publication Date
Volume
278
Identifiers
DOI: 10.1016/s0304-3940(99)00893-9
Keywords
  • Tau
  • Apolipoprotein E4
  • Alzheimer'S Disease
  • Polymorphism
  • Interaction
Disciplines
  • Biology
  • Medicine

Abstract

Abstract Searching for tau genetic variations which could be associated with risk for Alzheimer's disease (AD), we have performed a mutational analysis of a region containing the whole exon 11 of the tau gene, which encodes a microtubule binding region critical for tau self-assembly, and we have found a biallelic polymorphism at position +34 of intron 11 (IVS11+34G/A). We have analyzed the allelic frequencies of this polymorphism in a case-control sample (167 clinically diagnosed AD and 194 controls) and found that the presence of any G allele (genotypes AG+GG) is associated with a five-fold AD risk in individuals carrying the apolipoprotein E4 allele, strongly suggesting that the combined effect of tau and apoE is relevant in relation with AD pathogenesis.

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