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Down-regulation of the NKG2D ligand MICA by the human cytomegalovirus glycoprotein UL142

Authors
Journal
Biochemical and Biophysical Research Communications
0006-291X
Publisher
Elsevier
Publication Date
Volume
346
Issue
1
Identifiers
DOI: 10.1016/j.bbrc.2006.05.092
Keywords
  • Nk Cell
  • Cytotoxicity
  • Hcmv
  • Mica
  • Ul142
Disciplines
  • Biology

Abstract

Abstract Human cytomegalovirus (HCMV) employs a variety of strategies to modify or evade the host immune response, and natural killer (NK) cells play a crucial role in controlling cytomegalovirus infections in mice and humans. Activation of NK cells through the receptor NKG2D/DAP10 leads to killing of NKG2D ligand-expressing cells. We have previously shown that HCMV is able to down-regulate the surface expression of some NKG2D ligands, ULBP1, ULBP2, and MICB via the viral glycoprotein UL16. Here, we show that the viral gene product UL142 is able to down-regulate another NKG2D ligand, MICA, leading to protection from NK cytotoxicity. UL142 is not able to affect surface expression of all MICA alleles, however, which may reflect selective pressure on the host to thwart viral immune evasion, further supporting an important role for the MICA–NKG2D interaction in immune surveillance.

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