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Effects of leukaemia inhibitory factor and other cytokines on murine and human myoblast proliferation

Authors
Journal
Journal of the Neurological Sciences
0022-510X
Publisher
Elsevier
Publication Date
Volume
112
Identifiers
DOI: 10.1016/0022-510x(92)90149-f
Keywords
  • Muscle Cells
  • Myoblasts
  • Cytokines
  • Leukaemia Inhibitory Factor
  • Proliferation

Abstract

Abstract It has been shown that leukaemia previously that inhibitory factor (LIF) transforming and growth factor-α (TGF-α) stimulate proliferation of primary culture of murine myoblasts. We now show that human myoblasts respond in a similar manner to LIF and TGF-α. These responses occur over a range of growth conditions. There are total additive effects in both human and murine myoblasts between LIF and TGF-α and LIF and fibroblast growth factor-β (FGF-β), but not between LIF and interleukin-6 (IL-6) or insulin-like growth factor 1 (IGF-1). The LIF response is initiated by a short exposure to the cytokine and is maintained for prolonged periods in its absence.

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