Affordable Access

Publisher Website

Positive and negative regulation of water channel aquaporins in human small intestine by cholera toxin

Authors
Journal
Microbial Pathogenesis
0882-4010
Publisher
Elsevier
Publication Date
Volume
32
Issue
6
Identifiers
DOI: 10.1006/mpat.2002.0502
Keywords
  • Cholera Toxin
  • Aquaporin
  • Water Channel
  • Diarrhoea
  • Small Intestine

Abstract

Abstract Analysis of osmotic water permeability of aquaporin (AQP) 1, AQP3 and AQP4, which are expressed in human small intestine, in the presence or absence of cholera toxin (CT) was performed using a Xenopus oocyte expression system. When treated with CT, water permeability of AQP4 was facilitated while that of AQP3 was suppressed. AQP1 did not show any significant change of water permeability when treated with CT. An adenylyl cyclase accelerator forskolin showed similar effects as CT did, suggesting that changes of the water permeability of AQP4 and AQP3 were due to an increase of intracellular cAMP concentration. A possibility that these AQPs are responsible molecules for causing acute secretory diarrhoea as in cholera is considered.

There are no comments yet on this publication. Be the first to share your thoughts.