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Inhibition of DNA synthesis and cell death

Authors
Journal
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression
0167-4781
Publisher
Elsevier
Publication Date
Volume
696
Issue
2
Identifiers
DOI: 10.1016/0167-4781(82)90023-9
Keywords
  • Dna Synthesis Inhibition
  • Cell Death
  • Hydroxyurea
  • Repetitive Dna Sequence

Abstract

Abstract The association between DNA synthesis inhibition and cell death in mouse L-cells was investigated using the drug hydroxyurea. This drug produces a preferential labelling of low molecular weight DNA and dose-response studies revealed a correlation between this effect and cytotoxicity. Investigation of the reassociation kinetics of DNA labelled during hydroxyurea inhibition showed an over-replication of middle repetitive sequences, but the concentration dependence of this effect was quite different to that of cytotoxicity.

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