Affordable Access

Publisher Website

Excitotoxic lesions of the subthalamic nucleus ameliorate asymmetry induced by striatal dopamine depletion in the rat

Authors
Journal
Behavioural Brain Research
0166-4328
Publisher
Elsevier
Publication Date
Volume
90
Issue
1
Identifiers
DOI: 10.1016/s0166-4328(97)00080-6
Keywords
  • Basal Ganglia
  • Parkinson'S Disease
  • Sensorimotor Asymmetry
  • Subthalamic Nucleus
  • Rat

Abstract

Abstract We investigated the effect of unilateral dorsal striatal dopamine depletion (by intrastriatal infusion of 6-OHDA), ibotenic acid lesions of the subthalamic nucleus (STN) and combined dopamine depletion and STN lesions on sensorimotor asymmetry using a test of somatosensory asymmetry [T. Schallert et al., Pharmacol. Biochem. Behav. 16 (1982) 455–462]. The unilateral striatal dopamine depletion resulted in a somatosensory asymmetry. This asymmetry was ameliorated in the rats with combined dopamine depletion and STN lesion, indicating the potential beneficial nature of STN inactivation in rats with striatal dopamine depletion.

There are no comments yet on this publication. Be the first to share your thoughts.