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Co-expression of Fos immunoreactivity in protein kinase (PKCγ)-positive neurones: quantitative analysis of a brain region involved in learning

Authors
Journal
Brain Research
0006-8993
Publisher
Elsevier
Publication Date
Volume
606
Issue
2
Identifiers
DOI: 10.1016/0006-8993(93)91000-i
Keywords
  • Protein Kinase C
  • Protein Kinase Cγ
  • C-Fos
  • Fos Protein
  • Chick
  • Intermediate And Medial Hyperstriatum Ventrale
  • Imprinting
  • Learning
Disciplines
  • Biology
  • Chemistry

Abstract

Abstract The expression of the gamma protein kinase C isoenzyme (PKCγ) and of the c- fos immediate early gene protein product Fos in the intermediate and medial hyperstriatum ventrale (IMHV) of day-old chicks was determined immunocytochemically. Previous research has shown that (a) there is a learning-related increase in the expression of Fos in the IMHV of the chick after imprinting; (b) PKCγ is expressed in neurones in most regions of the chick forebrain, including the IMHV. In the present study it was found that in imprinted chicks, 96.5% of neurones in the IMHV that expressed Fos also stained positively for PKCγ. These results raise the possibility of a functional connection between PKCγ activation and c- fos expression in neurones in general, and in particular in neurones in the IMHV that are involved in learning.

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