Nervous system disorder with numerous clinical syndromes including stroke can be a manifestation of various multisystem connective tissue diseases. Cerebrovascular accident can develop early in the course of the disease, it can be either mild or dominant lesion. New diagnostic possibilities, particularly imaging methods provide more accurate diagnosis as well as new data on the character of the lesion. Treatment usually depends on the activity of underlying disease. With better understanding of the pathogenesis of nervous system disorder, new treatment modalities will be created.