This paper outlines the general context of the U.S.- Canada and U.S. – Mexice borderlands and provides an overview of emerging transnational regions based on integrative and cooperative relationship. It has been argued that the model of cooperation, advanced recently by Patchell (1966) is a usable framework for understanding of contemporary processes that transcend the borders in North America. Economic factors are the major driving force of increased transborder cooperation. In absenceof common policies and a central funding agency for a systematic approach to the development of transborder regions, various approaches to formal and informal relationship between government and private sectors have developed to coordinate and enhance economic activities on both sides of the border, representing a mosaic of regionspecific approaches. Several of recently surfaced regional concepts, such as PWNER, CREA, CANAMEX, CAMREAL, partially represent the strangthening of functional ties between north and south, and to some extent reflect the formal integration encouraged by the North American Free Trade Agreement (NAFTA).