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Distribution of transforming growth factor-β1in human astrocytomas

Authors
Journal
Human Pathology
0046-8177
Publisher
Elsevier
Publication Date
Volume
23
Issue
11
Identifiers
DOI: 10.1016/0046-8177(92)90297-g
Keywords
  • Transforming Growth Factor-β
  • Astrocytoma
  • Neovas-Cularization
  • Tumor-Infiltrating Lymphocytes
  • Tumor-Infiltrating Macrophages
  • Immunohistochemistry
Disciplines
  • Chemistry

Abstract

Abstract We used immunohistochemical techniques to study the distribution of transforming growth factor-β 1 (TGF-β 1) and infiltrating lymphocytes and macrophages in human astrocytomas. Thirteen of 15 grade 4 astrocytomas (glioblastomas) showed staining with anti-TGF-β 1 antibody, predominantly in proliferating endothelial complexes and surrounding small and medium-sized blood vessels. Brain tissue microscopically free of tumor cells (n = 8) and more differentiated astrocytomas of varying grade (1 to 3; n = 6) devoid of endothelial proliferation did not stain with anti-TGF-β 1. Normal brain contained only rare lymphoreticular cells. The majority of astrocytomas studied, however, contained T lymphocytes and macrophages with smaller numbers of B lymphocytes. The lymphoreticular infiltrates were concentrated primarily in close proximity to blood vessels. Within an individual tumor perivascular regions staining for TGF-β 1 never contained more than occasional T lymphocytes. Perivascular regions not staining for TGF-β 1 frequently contained low to high numbers of T lymphocytes. The inverse relationship in the distribution of TGF-β 1 and lymphocyte infiltrates is compatible with a functional relationship between this cytokine and an immune effector cell response to glioblastomas.

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