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Synthesis of pyrimidines from 2-trichloromethyl-4-dimethylamino-1,3-diaza-1,3-butadienes and electron deficient acetylenes

Authors
Journal
Tetrahedron Letters
0040-4039
Publisher
Elsevier
Publication Date
Volume
33
Issue
24
Identifiers
DOI: 10.1016/s0040-4039(00)92660-1

Abstract

Abstract 2-Trichloromethyl-4-dimethylamino-1,3-diaza-1,3-butadienes(3), prepared from trichloroacetamidine(1) and amide acetals 2, readily react with electron deficient acetylenes 4 to give 2-trichloromethylpyrimidines 5. 1,3-Diaza-1,3-dienes 3 undergo [4π+2π] cycloaddition with activated acetylenes 4 providing pyrimidines 5.

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