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The correlation of metabolic and ultrastructural changes in emetine myocardial toxicity

Authors
Journal
American Heart Journal
0002-8703
Publisher
Elsevier
Publication Date
Volume
87
Issue
1
Identifiers
DOI: 10.1016/0002-8703(74)90397-4

Abstract

Abstract Emetine exerts a specific effect on mitochondrial function and structure. Its action is to inhibit oxidative phosphorylation as measured by mitochondrial oxygen consumption, ADP:O ratio, and the respiratory control ratio. Our observations corelate documented specific structural abnormality with a metabolic change. These results probably account for some of the cardiotoxicity known to result from administration of emetine.

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