Affordable Access

Trend Analysis of Gastric Cancer and Colorectal Cancer Mortality in Iran, 1995-2003

Shahid Beheshti University of Medical Sciences
Publication Date
  • Biology
  • Medicine


Background: Cancer is the third most common cause of death in Iran. Gastric cancer (GC) and colorectal cancer (CRC) are two important causes of mortality due to cancer. With regards to cancer mortality, data are important to monitor the effects of screening program, earlier diagnosis, demographic data and other prognostic factors. The aim of this study was to evaluate the mortality rates and trends from GC and CRC in Iranian population during a period of almost a decade, i.e. from 1995 to 2003.Methods: National death Statistic Reported by the Ministry of Health and Medical Education (MOH&ME) from 1995 to 2003, stratified by age group, sex, and cause of death are included in this study. CRC and GC were expressed as the annual mortality rates/100,000, general and/or per gender, and age group. Results: The general mortality rate of CRC slightly increased during the years under study from 0.44 to 2.54 and CRC mortality was higher for older age and male. The general mortality rates of GC showed a sharp increasing from 1.68 to 9.67. In addition to this, GC mortality rate was higher for male than female.Conclusion: Our study indicated remarkable increasing trends in GC and CRC mortality. So developing for a gastric cancer for both primary prevention and early detection programs and manage the delays of diagnosis is recommended to decrease the trend of GC mortality. For CRC, since the rate of CRC screening is very low in Iran, it is recommended that in Iran screening be started as a public program in order to control the mortality and burden of CRC in the future. Keywords: Colorectal cancer; Gastric cancer; Mortality; Trend analysis; IranPlease cite this article as: Pourhoseingholi MA, Faghihzadeh S, Hajizadeh E, Gatta G, Zali MR, Abadi AR. Trend Analysis of Gastric Cancer and Colorectal Cancer Mortality in Iran, 1995-2003. Iran J Cancer Prev.2011; Vol4, No1, P. 38-43.References1. Naghavi M. Death report from 23 provinces in Iran. 1st edition. 2004; Ministry of Health and Medical Education; Tehran.2. Mosavi-Jarrahi A, Mohagheghi MA. Epidemiology of esophageal cancer in the high-risk population of Iran. Asian Pac J Cancer Prev. 2006; 7, 375-80.3. Cancer incidence in the Tehran Metropolitan. Second report of the Tehran Population-Based cancer registry, the cancer Institute cancer research centre. 2007.4. Moghimi-Dehkordi B, Safaee A, Zali MR. Comparison of colorectal and gastric cancer: survival and prognostic factors. Saudi J Gastroenterol. 2009 Jan; 15(1):18-23.5. Samarasam I, Chandran BS, Sitaram V, Perakath B, Nair A, Mathew G. Palliative gastrectomy in advanced gastric cancer: is it worthwhile? ANZ J Surg. 2006; 76(1-2):60-3.6. Murray CJ, Lopez AD. Alternate projections of mortality and disability by cause 1999-2020: global burden of disease study. Lancet. 1997; 349, 1498-1504.7. Ozkan K, Turkkan E, Ender K, Mutlu D, Murat A, Nalan B, et al. 5-Fluorouracil, epirubicin and cisplatin in the treatment of metastatic gastric carcinoma: a retrospective analysis of 68 patients. Indian J Cancer. 2005; 42(2):85-8.8. Pourhoseingholi MA, Hajizadeh E, Moghimi Dehkordi B, Safaee A, Abadi A, Zali MR. Comparing Cox regression and parametric models for survival of patients with gastric carcinoma. Asian Pac J Cancer Prev. 2007 Jul-Sep; 8(3):412-6.9. Moghimi-Dehkordi B, Safaee A, Pourhoseingholi MA, Zali MR. Effect of demographic and clinicopathologic factors on prognosis of early gastric cancer in Iran. Asian Pac J Cancer Prev. 2008 Oct-Dec; 9(4):585-8.10. Pourhoseingholi MA, Moghimi-Dehkordi B, Safaee A, Hajizadeh E, Solhpur A, Zali MR. Prognostic factors in gastric cancer using log-normal censored regression model. Indian J Med Res. 2009 Mar; 129(3):262-7.11. Pourhoseingholi MA, Vahedi M, Moghimi-Dehkordi B, Pourhoseingholi A, Ghafarnejad F, Maserat E, et al. Burden of hospitalization for gastrointestinal tract cancer patients - Results from a cross-sectional study in Tehran. Asian Pac J Cancer Prev. 2009; Jan-Mar; 10(1):107-10.12. Sonnenberg A, Delcò F, Inadomi JM. Cost-effectiveness of colonoscopy in screening for colorectal cancer. Ann Intern Med. 200; 17; 133(8):573-84.13. Parkin DM. Global cancer statistics in the year 2000. Lancet Oncol. 2001, 2:533-43.14. Moghimi-Dehkordi B, Safaee A, Zali MR. Prognostic factors in 1,138 Iranian colorectal cancer patients. Int J Colorectal Dis. 2008 Jul; 23(7):683-8.15. Azadeh S, Moghimi-Dehkordi B, Fatemi SR, Pourhoseingholi MA, Ghiasi S, Zali MR. Colorectal cancer in Iran: an epidemiological study. Asian Pac J Cancer Prev. 2008 Jan-Mar; 9(1):123-6.16. Burnet NG, Jefferies SJ, Benson RJ, Hunt DP, Treasure FP. Years of life lost (YLL) from cancer is an important measure of population burden – and should be considered when allocating research funds British Journal of Cancer. 2005; 92, 241-5.17. Naghavi M. Death report from 18 provinces in Iran. 1st edition. 2002; Ministry of Health and Medical Education, Tehran, Iran.18. Naghavi M. Death report from 18 provinces in Iran. 1st edition. 2003; Ministry of Health and Medical Education, Tehran, Iran.19. National Statistics Center, Online Publications at: Levi F, Lucchini F, La Vecchia C, Negri E. Trends in mortality from cancer in European Union, 1955-94. Lancet. 1999; 354:742-3.21. Levi F, Lucchini F, Negri E, Boyle P, La Vecchia C. Cancer mortality in Europe, 1995-1999, and an overview of trends since 1960. Int J Cancer. 2004; 110:155-169.22. Parkin DM. International variation. Oncogene. 2004; 23(38):6329-40.23. Sadjadi A, Nouraie M, Mohagheghi MA, Mousavi-Jarrahi A, Malekzadeh R, Donald Maxwell P. Cancer occurrence in Iran in 2002, an international prospective. Asian Pacific J Cancer Prev. 2005; 6: 359 –63.24. Somi MH, Farhang S, Mirinezhad SK, Naghashi S, Sief-Farshad M, Golzari M. Cancer in East Azerbaijan, Iran: Results of a Population-based Cancer Registry. Asian Pac J Cancer Prev. 2008; 9:327–30.25. Malekzadeh R, Nasseri-Moghaddam S. Reducing gastric cancer mortality in developing countries: learning from the experience in Japan. Arch Iran Med. 2008 Sep; 11(5):588-90.26. Moghimi-Dehkordi B, Safaee A, Zali MR. Survival rates and prognosis of gastric cancer using an actuarial life-table method. Asian Pac J Cancer Prev. 2008 Apr-Jun; 9(2):317-21.27. Movahedi M, Afsharfard A, Moradi A, Naser Moadeli A, Khoshnevis J, Fattahi F, Akbari ME. Survival rate of gastric cancer in Iran. JRMS. 2009; 14 (6):367-73.28. Mehrabian AA, Esna-Ashari F, Zham H, Hadizadeh M, Bohlooli M, Khayamzadeh M, Akbari ME. Gastric Cancer Prevalence, According To Survival Data in Iran (National Study-2007). Iranian J Publ Health.2010; 39(3): 27-31.29. Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics 2002. CA Cancer J Clin. 2005;55:74-108.30.Verdecchia A, Mariotto A, Gatta G, Bustamante-Teixeira MT, Ajiki W. Comparison of stomach cancer incidence and survival in four continents. Eur J Cancer. 2003; 39:1603-9.31. Fuchs CS, Mayer RJ. Gastric carcinoma. Engl J Med 1995; 333:32-41.32. Yang L. Incidence and mortality of gastric cancer in China. World J Gastroenterol. 2006 Jan 7; 12(1):17-20.33. Matsuzaka M, Fukuda S, Takahashi I, Shimaya S, Oyama T, Yaegaki M, et al. The decreasing burden of gastric cancer in Japan. Tohoku J Exp Med. 2007 Jul; 212(3):207-19.34. Winawer SJ. Gastric cancer: Worldwide burden and prevention opportunities. Chin J Dig Dis. 2005; 6(3):107-9.35. Mousavi SM, Somi MH. Gastric Cancer in Iran 1966-2006. Asian Pacific J Cancer Prev. 2009; 10, 407-12.36. Parkin DM, Bray FI, Devesa SS. Cancer burden in the year 2000: the global picture. Eur J Cancer. 2001; 37(suppl 8):S4-S66.37. Fernandez E, La Vecchia C, Gonzalez JR, Lucchini F, Negri E, Levi F. Converging patterns of CR mortality in Europe. Eur J Cancer 2005; 41:430-437.38. Valean S, Mircea PA, Oprea L, Frentiu D, Popescu G, Nagy G, et al. Trends of mortality rates from gastric cancer and colorectal cancer in Romania 1955-2003. J Gastrointestin Liver Dis. 2006 Jun; 15(2):111-5.39. Center for Disease Control and Prevention, Noncommunicable Deputy Cancer Office. Iranian Annual National Cancer Registration Report 2005 – 2006[in Persian]. Tehran (Iran): Ministry of Health and Medical Education; 2007.40. Hosseini SV, Izadpanah A, Yarmohammadi H. Epidemiological changes in colorectal cancer in Shiraz, Iran: 1980–2000. ANZ J Surg. 2004; 74:547–9.41. Moradi A, Khayamzadeh M, Guya MM, Mirzaei HR, Salmanian R, Rakhsha A, Akbari ME. Survival of colorectal cancer in Iran. Asian Pac J Cancer Prev. 2009 Oct-Dec; 10(4):583-6.42. Esna-Ashari F, Sohrabi MR, Abadi AR, Mehrabian AA, Mofid B, Bohluli M, Akbari ME. Colorectal Cancer Prevalence According to Survival Data in Iran-2007. IJCP 2009; 2(1): 15-8.43. Malekzadeh R, Bishehsari F, Mahdavinia M, Ansari R. Epidemiology and molecular genetics of colorectal cancer in Iran: a review. Arch Iran Med. 2009 Mar; 12(2):161-9.44. Ansari R, Mahdavinia M, Sadjadi A, Nouraie M, Kamangar F, Bishehsari F, et al. Incidence and age distribution of colorectal cancer in Iran: results of a population-based cancer registry. Cancer Lett. 2006; 240:143-7.

There are no comments yet on this publication. Be the first to share your thoughts.