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The micronucleus assay with mouse peripheral blood reticulocytes using acridine orange-coated slides with triethylenemelamine

Authors
Journal
Mutation Research/Genetic Toxicology
0165-1218
Publisher
Elsevier
Publication Date
Volume
278
Identifiers
DOI: 10.1016/0165-1218(92)90222-l
Keywords
  • Micronucleus Test
  • Peripheral Blood Cells
  • Acridine Orange-Coated Slide Method
  • Triethylenemelamine

Abstract

Abstract A micronucleus assay using mouse peripheral blood and supravital staining with acridine orange (AO) was validated by two laboratories on triethylenemelamine-treated mice. Dose- and time-dependent increases in micronucleated peripheral reticulocytes were observed. This new method can be used as an alternative to the conventional bone marrow micronucleus assay.

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