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2D-spatial/2D-spectral spectroscopic imaging of intracerebral gliomas in rat brain.

Authors
Type
Published Article
Journal
Magnetic resonance in medicine
Publication Date
Volume
43
Issue
2
Pages
211–219
Identifiers
PMID: 10680684
Source
Medline
License
Unknown

Abstract

1H-MR spectroscopy in vivo is often hampered by poor spectral resolution. Spectral overlap can be avoided with two-dimensional spectroscopic techniques. Correlation peak imaging has been implemented to measure unambiguously the distribution of several metabolites in a rat brain glioma model. Acquisition-weighted spectroscopic imaging reduced the experimental time and provided excellent spatial localization. The choice of an appropriate spectral acquisition window granted good sensitivity. Spectroscopic images presenting a full two-dimensional spectrum in every image pixel were acquired in seven rats at 7 Tesla in 195 min, with a nominal voxel volume of 75 microl. Among other metabolites, the distribution of hypotaurine, phosphoethanolamine, alanine, and even glucose could be visualized both in the C6-glioma and in the unaffected brain.

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