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Chapter 3 Biology of the Eosinophil

Elsevier Science & Technology
DOI: 10.1016/s0065-2776(08)01003-1
  • Biology
  • Medicine


Abstract In this review, we aim to put in perspective the biology of a multifunctional leukocyte, the eosinophil, by placing it in the context of innate and adaptive immune responses. Eosinophils have a unique contribution in initiating inflammatory and adaptive responses, due to their bidirectional interactions with dendritic cells and T cells, as well as their large panel of secreted cytokines and soluble mediators. The mechanisms and consequences of eosinophil responses in experimental inflammatory models and human diseases are discussed.

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