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Non-invasive cardiac magnetic resonance and electrical myocardial imaging assessment of CRT in patients with heart failure and left bundle branch block

Authors
Journal
Journal of Cardiovascular Magnetic Resonance
1097-6647
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Volume
13
Identifiers
DOI: 10.1186/1532-429x-13-s1-o92
Keywords
  • Oral Presentation
Disciplines
  • Medicine

Abstract

Non-invasive cardiac magnetic resonance and electrical myocardial imaging assessment of CRT in patients with heart failure and left bundle branch block ORAL PRESENTATION Open Access Non-invasive cardiac magnetic resonance and electrical myocardial imaging assessment of CRT in patients with heart failure and left bundle branch block Fady Dawoud1*, Karl Schuleri1, Rozann Hansford1, Kristine Evers1, B Milan Horacek2, Henry Halperin1, Albert Lardo1 From 2011 SCMR/Euro CMR Joint Scientific Sessions Nice, France. 3-6 February 2011 Introduction CRT is an effective treatment for patients with heart failure and intraventricular conduction delay. However, clinical non-response rates remain unacceptably high; emphasizing the need for improved selection criteria. Central to the underlying mechanism of resynchroniza- tion is the relationship between mechanical and electri- cal activation. The purpose of this study was to demonstrate that mechanical and electrical activation can be quantified in patients with CRT devices combin- ing cardiovascular magnetic resonance (CMR) and elec- trical myocardial imaging (EMI). Purpose Non-invasively characterize mechanical and electrical activation patterns in patients undergoing cardiac resyn- chronization therapy (CRT) Methods Patients implanted with biventricular CRT for greater than 9 months (N=10) were mapped with 120 body sur- face electrodes during both intrinsic activation (device off) and CRT pacing. CMR tagging was also acquired with pacing on/off to perform strain analysis. The cir- cumferential uniformity ratio (CURE) was computed to 1Johns Hopkins University, Baltimore, MD, USA Full list of author information is available at the end of the article Figure 1 (A)Mid-myocardial, mid-systole short axis MRI tagging image in a patient with CRT device showing sufficient tag quality for strain analysis. (B)Reconstructed electrical activation times during intrinsic activation showing RV preceding LV activation. (C)Synchronized electrical activat

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