Affordable Access

Publisher Website

Analytical considerations for microdialysis sampling

Authors
Journal
Advanced Drug Delivery Reviews
0169-409X
Publisher
Elsevier
Publication Date
Volume
45
Identifiers
DOI: 10.1016/s0169-409x(00)00114-9
Keywords
  • Liquid Chromatography
  • Capillary Electrophoresis
  • Electrochemical Detection
  • Fluorescence Detection
  • Mass Spectrometry
  • Biosensor
Disciplines
  • Design

Abstract

Abstract Adaptations in microdialysis probe designs have made it possible to obtain samples from the extracellular fluid of a variety of tissues with high temporal resolution. The resulting small volume samples, often with low concentration of the analyte(s) of interest, present a particular challenge to the analytical system. Rapid separations can be coupled on-line with microdialysis to provide near real-time data. By combining microdialysis sampling with a liquid chromatographic or capillary electrophoretic separation and a highly sensitive detection method, a separation-based sensor can be developed. Such sensors have been applied to the investigation of drug entities as well as to study endogenous analytes.

There are no comments yet on this publication. Be the first to share your thoughts.