Affordable Access

Publisher Website

Polyribosome dynamics at steady state

Authors
Journal
Journal of Theoretical Biology
0022-5193
Publisher
Elsevier
Publication Date
Volume
22
Issue
3
Identifiers
DOI: 10.1016/0022-5193(69)90018-6
Disciplines
  • Biology

Abstract

Abstract The Warner-Rich model for monocistronic polyribosomes is analyzed quantitatively by computer simulation. Its kinetic parameters may be directly related to those which are experimentally observable at steady state. Although simple cases can be solved exactly, it is found that computer simulation is a superior technique for polysomes of biologically significant size. The rate of protein synthesis, polysome distribution, ribosome gradient along the messenger, and distribution of nascent peptide lengths are given over the full range of variability of the free parameters for messenger RNA (mRNA) with a length of 150 codons. Measurements are suggested to test the validity of the Warner-Rich model, or certain of its predictions.

There are no comments yet on this publication. Be the first to share your thoughts.