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Do Macrophage Innate Immune Receptors Enhance Atherogenesis?

Authors
Journal
Developmental Cell
1534-5807
Publisher
Elsevier
Publication Date
Volume
5
Issue
5
Identifiers
DOI: 10.1016/s1534-5807(03)00329-0

Abstract

Abstract Macrophages play a central role in both innate immunity to infection and atherosclerosis. Castrillo and colleagues report that selected microbial agonists for Toll-like receptors strongly inhibit LXR-mediated cholesterol efflux from macrophages. TLR-LXR crosstalk could explain how nonspecific microbial infections promote atherogenesis.

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