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MPTP toxicity in the mouse brain and vitamin E

Authors
Journal
Neuroscience Letters
0304-3940
Publisher
Elsevier
Publication Date
Volume
108
Issue
3
Identifiers
DOI: 10.1016/0304-3940(90)90665-v
Keywords
  • 1-Methyl-4-Phenyl-1
  • 2
  • 3
  • 6-Tetrahydropyridine
  • Vitamin E
  • Oxidative Stress
  • Substantia Nigra
  • Striatum

Abstract

Abstract 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) caused transient alterations in vitamin E levels in every brain region examined. However, vitamin E returned to normal levels within a few hours in all brain regions but the substantia nigra, where at 2 days vitamin E levels first rose above normal levels. Vitamin E deficient mice were much more susceptible to MPTP toxicity than controls, in terms of lethality and DOPAC depletion in the substantia nigra. However, in the same vitamin E deficient mice, the striatum was partially protected from neurotransmitter and metabolite depletion by MPTP. The mechanism of toxicity of MPTP may differ in the striatum and the midbrain.

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