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Synthesis and characterization of cyclomaltoheptaose-based metal chelants as probes for intestinal permeability

Authors
Journal
Carbohydrate Research
0008-6215
Publisher
Elsevier
Publication Date
Volume
267
Issue
1
Identifiers
DOI: 10.1016/0008-6215(94)00289-r
Keywords
  • Cyclomaltoheptaose
  • β-Cyclodextrin
  • Monosubstituted Derivatives
  • Ethylenediaminetetraacetate
  • Cyclic Disulfide

Abstract

Abstract The syntheses of two cyclomaltoheptaose-based metal chelants, cyclomaltoheptaose-ethylenediaminetetraacetate (CD-EDTA) and cyclomaltoheptaose-diamide-disulfur (CD-DADS), are described. The chelant moieties are attached to the 6-position of a single pyranose in the cyclomaltoheptaose via a short diamine spacer chain. Characterization of these novel chelants has been achieved using NMR and MS techniques. The peculiar fluxional properties of the CD-EDTA molecules is also discussed.

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