Affordable Access

Publisher Website

Back to past leeches: repeated phlebotomies and cardiovascular risk

Authors
Journal
BMC Medicine
1741-7015
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Volume
10
Issue
1
Identifiers
DOI: 10.1186/1741-7015-10-53
Keywords
  • Commentary
Disciplines
  • Design
  • Medicine

Abstract

In patients with metabolic syndrome, body iron overload exacerbates insulin resistance, impairment of glucose metabolism, endothelium dysfunction and coronary artery responses. Conversely, iron depletion is effective to ameliorate glucose metabolism and dysfunctional endothelium. Most of its effectiveness seems to occur through the amelioration of systemic and hepatic insulin resistance. In a study published by BMC Medicine, Michalsen et al. demonstrated a dramatic improvement of blood pressure, serum glucose and lipids after removing 550 to 800 ml of blood in subjects with metabolic syndrome. This effect was apparently independent of changes in insulin resistance, in contrast to previous cross-sectional and cohort studies investigating the association between iron overload, insulin resistance and cardiovascular disease. Despite drawbacks in the study design, its findings may lead the way to investigations aimed at exploring iron-dependent regulatory mechanisms of vascular tone in healthy individuals and patients with metabolic disease, thus providing a rationale for novel preventive and therapeutic strategies to counteract hypertension. Please see related article: http://www.biomedcentral.com/1741-7015/10/54

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

Polycythaemia vera in a dog treated by repeated ph...

on The Veterinary quarterly September 1993

The effect of repeated phlebotomies in hemochromat...

on Journal of Laboratory and Clin... April 1952

Radioiron studies in hemochromatosis; the effects...

on Journal of Laboratory and Clin... February 1955
More articles like this..