Affordable Access

Publisher Website

The Neurotoxic Properties of Pesticides

Authors
Publisher
Elsevier Science & Technology
Identifiers
DOI: 10.1016/s0074-7750(05)30007-3
Disciplines
  • Chemistry
  • Medicine

Abstract

Publisher Summary The use of pesticides in homes, schools, food, and water provides ample opportunity for human exposure. Organophosphates (OPs) are the most common pesticides in current use. In addition to the neurotoxicity of organochlorines, they have been shown to have effects on the endocrine system. Semen quality has been shown to be impaired by exposure to alachlor and atrazine, and the feminization of male frogs has been detected. Decreased acetylcholinesterase (AChE) activity is not the sole mechanism of OP neurotoxicity; the correlation between cholinesterase and pseudocholinesterase activities and neuronal damage is not strong. In addition to their action on AChE, OPs have been found to affect adenyl cyclase. Pyrethroids are synthetic molecules that chemically resemble the natural pesticide secreted by chrysanthemums. Although generally regarded as safe, pyrethroids are not innocuous; they both activate and inactivate gates of sodium channels, thereby resulting in prolonged opening, with membrane depolarization, repetitive discharges leading to excess nervous system stimulation, and hyperexcitatory symptoms.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

Neurotoxicity of pesticides.

on Journal of agromedicine 2007

[Neurotoxicology of pesticides].

on Brain and nerve = Shinkei kenk... January 2015

Neurotoxicity of pesticides: a brief review.

on Frontiers in Bioscience 2008

Neurotoxic Pesticides and Neurologic Effects

on Neurologic Clinics Jan 01, 2011
More articles like this..