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Effect of endothelin on systemic and regional hemodynamics in rats

Authors
Journal
European Journal of Pharmacology
0014-2999
Publisher
Elsevier
Publication Date
Volume
170
Identifiers
DOI: 10.1016/0014-2999(89)90144-1
Keywords
  • Blood Flow
  • Cardiac Output
  • Endothelin
  • Hemodynamics
  • Vascular Resistance

Abstract

Abstract In this study we analyzed the changes in systemic haemodynamics induced by endothelin, 1 nmol/kg, given as an i.v. bolus to anaesthetized rats. Endothelin induced a dramatic decrease in cardiac output whereas the total peripheral resistance increased more than two times. In addition, renal blood flow decreased while renal vascular resistance increased to a similar extent. A marked decrease in blood flow to the splanchnic organs was also observed. In conclusion, endothelin seems to modulate peripheral vasomotor tone, at least under certain conditions.

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