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Proceedings: Distribution and radiosensitization in vivo piromelitic acid.

British Journal of Cancer
Nature Publishing Group
Publication Date
  • Research Article


766 PROCEEDINGS OF THE EUROPEAN SOCIETY FOR RADIATION BIOLOGY not changed significantly. By means of this agent, hypoxic CFU could be identified in the bone marrow of restrained mice but not in pentobarbitone anaesthetized mice, indicating that the radioprotective effect of pentobarbitone anaesthesia is caused by some mechanism other than hypoxia. We also showed that pentobarbitone prevents the recruitment of resting mouse bone marrow CFU into S phase following x-irradiation. Evidence for a higher radiosensitivity of mouse bone marrow CFU in S phase com- pared with resting CFU was presented by Duplan and Feinendegen (Proc. Soc. exp. Biol. Med., 1970, 134, 319). This might explain the radioprotective effect of pento- barbitone anaesthesia during irradiation. DISTRIBUTION AND RADIOSENSI- TIZATION IN VIVO OF PIROMELITIC ACID. F. SANZ SANCHEZ, A. ANADON NAVARRO, A. GOICOECHEA MAYO, R. MARTI- NEZ LARRANAGA and M. D. ASTUDILLO, Department of Pharmacology, Madrid, Veter- inary Faculty and Co-ordinated Center of Pharmacology, CSIC. To test piromelitic anhidride as a radio- sensitizer in vivo and with acute and subacute toxicity established, a preparatory study was conducted of tissue distribution and blood levels. The LD50 was 1 gr/kg administered intra- venously. The oral dosage of 1 gr/kg during 3 weeks did not cause noticeable variations in weight, food consumption and other parameters. To calculate the distribution kinetics of piromelitic acid- 3H at pH 7, using oral doses 1/5-LD50, animals were killed at intervals of 15 min, 30 min, 1, 2, 3, 6, 9, 24 and 48 h and blood samples taken; later brain, heart, lung, liver, kidney, intestine, muscle and skin samples were examined to determine the relation between per cent activity/mg min at time intervals and ratios of fresh organ to dry organ weight; maximum activity was reached in 30 min. This study of a radiosensitizer was con- ducted using Swiss/D mice as controls, irradiated and non-irradiated, inoculated with ascitic Ehrlich tumour cells. RAD

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