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Fine structure of murine pulmonary adenocarcinomata induced by treatment with 20-methylcholanthrene in organ culture

Authors
Journal
European Journal of Cancer (1965)
0014-2964
Publisher
Elsevier
Publication Date
Volume
6
Issue
6
Identifiers
DOI: 10.1016/0014-2964(70)90067-8
Disciplines
  • Medicine

Abstract

Abstract Mouse lung tissue was treated with 20-methylcholanthrene in vitro and then implanted into host animals to await the appearance of tumours. The fine structure of pulmonary adenocarcinomata induced by this method was studied and found to resemble, in some respects, that of similarly induced adenomata and of mouse lung tumours arising spontaneously or induced in vivo. Ultrastructural differences between the adenocarcinomata and the previously described adenomata included increased irregularity of cell-surface membranes, disaggregation of ribosomes and decreased numbers of specific cytoplasmic lamellar inclusion bodies. These differences, as well as the greater variations in cell structure which were observed, appeared to be related to the acquisition of a malignant character by these tumours.

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