Affordable Access

Publisher Website

Hedgehog and Gli Signaling in Embryonic Mammary Gland Development

Authors
Journal
Journal of Mammary Gland Biology and Neoplasia
1083-3021
Publisher
Springer-Verlag
Publication Date
Volume
18
Issue
2
Identifiers
DOI: 10.1007/s10911-013-9291-7
Keywords
  • Article
Disciplines
  • Biology

Abstract

The first mouse mutation associated with a heritable defect in embryonic mammary gland development was Extratoes. It represents a functional null-mutation of the gene encoding Gli3, which is best known as a transcription factor mediating canonical Hedgehog (Hh) signaling. Here we review the roles of Hh and Gli proteins in murine embryonic mammary development. We propose that an off-state for Hh signaling, mediated by Gli3-repressor, is determinant for induction of a mammary instead of hair follicle fate in the trunk surface ectoderm.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

Hedgehog signaling in mammary gland development an...

on Journal of Mammary Gland Biolo... September 2007

Hedgehog signaling in mouse mammary gland developm...

on Journal of Mammary Gland Biolo... January 2001

Ectodysplasin/NF-κB signaling in embryonic mammary...

on Journal of Mammary Gland Biolo... June 2013
More articles like this..