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Hedgehog and Gli Signaling in Embryonic Mammary Gland Development

Authors
Journal
Journal of Mammary Gland Biology and Neoplasia
1083-3021
Publisher
Springer-Verlag
Publication Date
Volume
18
Issue
2
Identifiers
DOI: 10.1007/s10911-013-9291-7
Source
Legacy
Keywords
  • Article
Disciplines
  • Biology

Abstract

The first mouse mutation associated with a heritable defect in embryonic mammary gland development was Extratoes. It represents a functional null-mutation of the gene encoding Gli3, which is best known as a transcription factor mediating canonical Hedgehog (Hh) signaling. Here we review the roles of Hh and Gli proteins in murine embryonic mammary development. We propose that an off-state for Hh signaling, mediated by Gli3-repressor, is determinant for induction of a mammary instead of hair follicle fate in the trunk surface ectoderm.

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